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Feverfew compound gets at leukemia roots

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Feverfew compound gets at leukemia roots

Wednesday, February 23, 2005A compound in the common daisy-like plant feverfew kills human leukemia stem cells and could form the basis for newer, more effective drugs for the disease.

American researchers at the University of Rochester Medical Center in New York say that it could take months to develop a useable drug from the compound, parthenolide.

However, they are working to do so with chemists at the University of Kentucky who have identified a water-soluble molecule with the same properties. The US National Cancer Institute has also accepted the work into its rapid access program, which aims to speed experimental drugs into human clinical trials.

“This research is a very important step in setting the stage for future development of a new therapy for leukemia,” says Rochester researcher Craig Jordan. “We have proof that we can kill leukemia stem cells with this type of agent, and that is good news.”

Parthenolide appears to target the roots of myeloid leukemia, stem cells, while current treatments including the relatively new drug Gleevec don’t. So, “You’re pulling the weed without getting to the root,” says Jordan.

Used for centuries to fight fevers, inflammation and arthritis, feverfew earned interest from the Rochester researchers after other scientists showed that it could prevent skin cancer in animal models.

So the researchers investigated how a concentrated form of the plant component parthenolide would affect leukemia cells and normal cells.

Comparing the impact of parthenolide to the common chemotherapy drug cytarabine, they found that parthenolide selectively killed leukemia cells while sparing normal cells better.

While the findings suggest that parthenolide is a good starting point for new drugs, people with leukemia aren’t being encouraged to take high doses of feverfew as they could not take enough of the remedy to halt the disease.

The research is reported in the journal Blood.

Retrieved from “https://en.wikinews.org/w/index.php?title=Feverfew_compound_gets_at_leukemia_roots&oldid=1985493”

Enjoy A Better Way Of Life With The Right Shreveport Rentals

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Did you have a hard day at work yesterday? Did you get home enjoy a bath in your oval Roman tub and then fall asleep under your ceiling fan? If not, you need to find an apartment that will help you to improve your lifestyle. The world can be stressful. However, when you walk into your apartment all of those troubles needed to be washed away. The right apartment will help you to do just that. It will make your lifestyle easier and more relaxed. Thus, you will be able to enjoy a gourmet kitchen, open layout and a private patio. Your life improves when your surroundings improve. That is why people want more out of an apartment than just walls and a bed. If you feel the same, it is time that you did something about it. It is time that you got off your couch and started touring the best Shreveport Rentals. You will be glad you did.

Do you enjoy standing at the sink and washing piles of dishes? Well, there is no reason to do it. You can rent a luxury apartment that features a dishwasher. Further, you can also expect to find a self-cleaning oven and plenty of space to prepare your meals. In fact, after you have prepared a wonderful meal for your significant other, you should dine on your private patio and enjoy the good weather. When you live in an apartment that offers luxury, you can enjoy all the amenities with your significant other.

How do you feel about a late night tennis match with your significant other? Are you thinking that it will be too dark at night to see the ball? Think again. The best properties feature a lighted tennis court. So, there is no reason not to enjoy a game. Further, after the game the two of you can walk along beautiful grounds back to your apartment. It is there that you relax again on the private patio and enjoy a glass of wine.

There is no reason to wait. It is time to start booking apartment tours. A better way of life is waiting for you.

Irish rock band The Cranberries’ lead singer Dolores O’Riordan dies at 46

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Irish rock band The Cranberries’ lead singer Dolores O’Riordan dies at 46

Thursday, January 18, 2018

On Monday, 46-year-old Dolores O’Riordan, lead singer of Irish rock band The Cranberries, was found dead, her publicist Lindsey Holmes confirmed; reports suggested she was found in her room at the London Hilton on Park Lane hotel. O’Riordan’s agent said she was in London, England, for a recording session. According to the police, her death was considered “unexplained” and no cause of death disclosed, though it was to be investigated.

Later one of the richest women of Ireland, O’Riordan joined the rock band, then known as “the Cranberry Saw Us”, as a teenager around 1989, after Niall Quinn had left the band. Also featuring drummer Fergal Lawler, bassist Mike Hogan and his brother Noel Hogan, the lead guitarist, the band released their first album Everybody Else Is Doing It, So Why Can’t We? in 1993. The debut album featuring single Linger was an international success. The band went on to release six more albums featuring O’Riordan’s voice, including Something Else, which was released last year.

A year later, in 1994, the band released their second studio album, No Need to Argue, which featured the song Zombie, a song about bombings related to Northern Ireland. Zombie topped the singles charts in various countries. In the same year, O’Riordan married Don Burton, sometime manager of the Duran Duran band. Their third album, To the Faithful Departed, was released in 1996. The album did not receive the acclamation of the first two.

In 2003, the band split, and it was reunited in 2009. During those six years, O’Riordan released two solo albums — Are You Listening? in 2007 and No Baggage in 2009. 2012’s Roses was the first album The Cranberries released after reunification.

Last year, O’Riordan revealed through London’s Metro newspaper she had been diagnosed with bipolar disorder. She also spoke of suffering from depression to The Irish News. In 2014, the singer was involved in assaulting a flight attendant and three police officials on a flight from New York, US to Ireland. She was fined €6000 (US$6600) after she pleaded guilty; medical reports said she suffered from mental illness during that incident. Last year, the band’s tour to North America and Europe for Something Else was cancelled partway through as O’Riordan suffered from a back problem.

After announcement of O’Riordan’s death, Irish prime minister Leo Varadkar tweeted, “For anyone who grew up in Ireland in the 1990s, Dolores O’Riordan was the voice of a generation. As the female lead singer of a hugely successful rock band, she blazed a trail and might just have been Limerick’s greatest ever rock star. RIP.”

The official twitter handle of The Cranberries posted a tweet saying, “We are devastated on the passing of our friend Dolores. She was an extraordinary talent and we feel very privileged to have been part of her life from 1989 when we started the Cranberries. The world has lost a true artist today.”

Born on September 6, 1971 in Ballybricken, a town in southeastern Ireland, O’Riordan had six older siblings. She wrote songs since the age of twelve. James Walton, a priest from her home area, said, “The plan is for her to be buried here at home. When that will be will depend on when her body is released.”

Dolores O’Riordan is survived by three children and ex-husband Don Burton.

Retrieved from “https://en.wikinews.org/w/index.php?title=Irish_rock_band_The_Cranberries%27_lead_singer_Dolores_O%27Riordan_dies_at_46&oldid=4576662”

Interview with Tony Ciufo, City Council candidate for Ward 10 in Mississauga, Canada

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Interview with Tony Ciufo, City Council candidate for Ward 10 in Mississauga, Canada

Friday, September 22, 2006

The upcoming 2006 Mississauga municipal election, to be held November 13, features an array of candidates looking to represent their wards in city council.

Wikinews contributor Nicholas Moreau has contacted as many candidates as possible, including Tony Ciufo, asking them to answer common questions sent in an email. There is no incumbent in the newly created ward; the sixteen resident competing for the position are Shah Rukh Alam, John Briers, Jamie Dookie, Dale D’Souza, Prag Euclid, Adnan Hashmi, Elias Hazineh, Jack Janiak, Fasal Javaid, Craig Lawrence, Sue M. McFadden, Patrick Mendes, Barbara Polis, Graziano Roti, Ali Tahmourpour, and Scott Wilson.

Retrieved from “https://en.wikinews.org/w/index.php?title=Interview_with_Tony_Ciufo,_City_Council_candidate_for_Ward_10_in_Mississauga,_Canada&oldid=4567780”

categories Uncategorized | January 9, 2021 | comments Comments (0)

Telstra becomes the first in the world to switch to HSPA+ wireless Internet technology

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Telstra becomes the first in the world to switch to HSPA+ wireless Internet technology

Wednesday, September 1, 2010

On Monday, Australian telecommunications company Telstra has introduced dual carrier HSPA+ standard for broadband Internet business customers in the Next G network. This is the first time this technology is being introduced on national scale. The bandwidths the users can deploy increased into two to three times, with Telstra becoming the world’s fastest national mobile broadband service. The switch started with enabling the service for premium users. After some feedback, Telstra may expand the plan.

The higher speeds for wireless are intended to simplify and ease multitasking of users.

John Paitaridis, Telstra’s executive director, network products and services in Enterprise & Government, said “One of the reasons we decided to launch first to Enterprise And Government and Business customers is that clients are saying that their ability to access applications quicker makes a difference to their business and when they start to equate time savings and doing calculations around productivity it does become a return on investment.”

Telstra Business Group Managing Director Deena Shiff also stated that the efforts aren’t as sudden as it might seem, having feedback of many users as the base.

Australians are telling us they can’t afford to be tied to the desk all day and these new speeds mean they can now access mobile broadband at speeds typically reserved for the office. We have been deploying the high-speed capability in the network since December 2009 and now, with the launch of the new Ultimate USB Modem, these new speeds are available to customers across all capital city CBDs and associated airports, selected metropolitan areas and in more than 100 regional locations. These high-speed zones cover approximately 50 per cent of the Australian population and match the areas of highest customer demand and will make the frustration of waiting around for files to download a thing of the past. In other metropolitan and regional areas, the Telstra Ultimate USB Modem offers typical download speeds ranging from 550kbps up to 8Mbps… Our customers have told us that they want higher speed mobile broadband so they can work more flexibly outside of the office and we are delighted to be the first in the world to offer these new blistering speeds on a national network. The new Telstra Ultimate USB Modem provides customers with the speeds needed to handle large files, multi-task and update cloud-hosted applications effortlessly on the go when they are in a coverage area.

Previous modems were able to reach peak speed 21Mbps, with real life speeds ranging from 0.5Mbps to 8 Mbps. The theoretically expected maximum of the new technology is 42Mbps with user speeds varying between 1.1 and 20 Mbps. The new speed is twice as fast. This is caused by that the dual-carrier “Evolved High-Speed Packet Access” technology allows networks to send and receive wireless data using two channels simultaneously. This technology can be deployed on Next G networks. Telstra switched to them in February, thus making the switch to HSPA possible now.

Telstra delayed the implementation of the new technology until elections end. This decision was intended to avoid wrong interpretation of them by Coalition. Coalition’s claims include that wireless networks can be an alternative to the Labor party “fibre-to-the-home” proposal to introduce more expensive wired Internet. The announcement of the new technology, initially planned on August 25, was delayed, with Telstra spokesman Craig Middleton explaining, “We just didn’t want to feel like we were influencing the [telecommunications] debate.”

The political parties have different plans on development and funds on the Internet. The Labor party aims to spend AUD 43 billion to bring 1 Gbps wired Internet nationwide, and the Coalition plans to spend AUD 6 billion to introduce a variety of improvements including upgrade of existing copper Internet as well as expansion of wireless Internet to support 12Mbps. Opposition leader Tony Abbott has said in the past that Australians shouldn’t assume wireless technologies won’t ever be comparable to fixed-line technology. Telstra’s upgrade shows that wireless broadband is reaching the 100 Mbps minimum speeds promised by Labor’s national broadband network.

Telstra has only 2000 devices which support the new technology. This is why the opportunity to try it out is being given only to the Business plan customers, and they receive it for the same price as they were paying for the previous NextG plan. Since October 5, the device will be available for sale, with the Business customers able to buy it with 75% discount and a prepaid data allowance. The upgrade is expected to cover roughly 50% of the population. This is happening at the same time as one of Telstra’s competitors Vodafone is doubling data download quotas on mobile cap plans.

As some testing showed, real life download speeds reached only about the half of the maximum. Telstra executive director of wireless Mike Wright explained that the predicted figures were the estimates, with real life speeds lower due to interfering environmental conditions: “It’s possible to achieve better than the typical user speed claims, but those claims occur in the ideal network environment with good signal quality. When you’re out on the streets you get a lot of variation where the network is subject to signal quality, your location and the network load.”

Retrieved from “https://en.wikinews.org/w/index.php?title=Telstra_becomes_the_first_in_the_world_to_switch_to_HSPA%2B_wireless_Internet_technology&oldid=2318493”

categories Uncategorized | January 8, 2021 | comments Comments (0)

Actress Mia Amber Davis dies aged 36

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Actress Mia Amber Davis dies aged 36

Thursday, May 12, 2011

American plus-size model and actress Mia Amber Davis has died at the age of 36 in Los Angeles, California. Davis, who appeared in the film Road Trip, died one day after undergoing routine knee surgery.

Davis was more than 6 feet (1.8 metres) tall and weighed over 300 pounds (136.1 kilogrammes). She was having the surgery after a prolonged basketball injury from her college days. The model returned to the hospital after feeling dizzy and later died there.

Michael Yard, Davis’ husband, was in New York at the time of her death. He spoke to TMZ, saying “I want to know what happened to my wife.”

Davis was also the editor of Plus Model Magazine. Magazine editor Madeline Jones commented on Davis’ death in a blog post, writing “Mia was a super model and industry leader because it was her love for the women she represented that kept pushing her when the industry itself did not embrace her. Anyone else would have given up, but Mia remained steadfast in her career, knowing that she was not just doing it for her own benefit, but for women of all ages.”

Davis is best remembered for her appearance in Road Trip. She played a heavyset woman named Rhonda who seduces a geek played by DJ Qualls.

Retrieved from “https://en.wikinews.org/w/index.php?title=Actress_Mia_Amber_Davis_dies_aged_36&oldid=3369366”

categories Uncategorized | January 5, 2021 | comments Comments (0)

Listeners call for tattooing of Muslims in America, supporting comedy skit

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Listeners call for tattooing of Muslims in America, supporting comedy skit

Saturday, December 9, 2006

When radio host Jerry Klein suggested that all Muslims in the United States should be identified with a crescent-shape tattoo,”the switchboard went from empty to totally jammed within minutes.” Some callers agreed with Klein, one saying that, “Not only do you tattoo them in the middle of their forehead but you ship them out of this country … they are here to kill us.” Another caller added that America should, “set up encampments like during World War Two with the Japanese and Germans”

At the end of the show Klein revealed that that it had been staged as a hoax. “I can’t believe any of you are sick enough to have agreed for one second with anything I said,” he told his AM 630 WMAL audience which covers Washington D.C., Northern Virginia and Maryland

“For me to suggest to tattoo marks on people’s bodies, have them wear armbands, put a crescent moon on their driver’s license on their passport or birth certificate is disgusting. It’s beyond disgusting.”

“Because basically what you just did was show me how the German people allowed what happened to the Jews to happen … We need to separate them, we need to tattoo their arms, we need to make them wear the yellow Star of David, we need to put them in concentration camps, we basically just need to kill them all because they are dangerous.”

Council on American-Islamic Relations Communications Director Ibrahim Hooper commented:

The public reaction to Mr. Klein’s courageous parody should be a wake-up call for American religious and political leaders who remain silent in the face of growing anti-Muslim bigotry in our society. Americans of all faiths must come together to marginalize extremists and to challenge ethnic and religious bigotry.
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categories Uncategorized | January 3, 2021 | comments Comments (0)

Dove ad viewed more than 3 million times on YouTube

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Dove ad viewed more than 3 million times on YouTube

Saturday, November 4, 2006

An advertisement for Dove beauty products has been viewed by well over three million people, without ever being on television. A copywriter from Ogilvy Toronto, the advertising agency that created a spot named “evolution”, uploaded the advertisement to video sharing website YouTube.

While the official upload of the ad itself has been viewed 1,119,262 times, there are dozens of copies of the ad on YouTube, adding to a minimum of 3,059,546 views. The official copy of the video is the website’s 12th most viewed this month, 53rd of all time.

Unofficial uploads have each received high levels of viewership, with 449595, 445322, 207906, 201670, 195265, 116501, and 102634 plays.

The agency did not originally intend to upload the video to YouTube, only display it on the company’s homepage. Staff member Tim Piper uploaded it to his account on October 6, about a week before it first got media coverage on Good Morning America.

The ad begins with a woman walking into a photo shoot. From there, she is primped and plucked by hair and makeup artists, then tweaked on a Photoshop-like program. The photo-manipulation is then posted on a billboard for the fictional “Easel Foundation Makeup” brand. Two young, teenage girls walk past, glancing at the board. “No wonder our perception of beauty is distorted” ends the ad in text, “Every girl deserves to feel beautiful just the way she is.”

The creative team for the ad included Tim Piper, Mike Kirkland, Janet Kestin, Nancy Vonk, directors T Piper (treatment and post production) and Yael Staav (live action) from Reginald Pike, Soho post production, Rogue editing, Vapor music, Gabor Jurina and Make-up: Diana Carreiro, and Reginald Pike.

The official French copy of the ad has only received 132 views, although it was only uploaded on November 2, 2006.

Retrieved from “https://en.wikinews.org/w/index.php?title=Dove_ad_viewed_more_than_3_million_times_on_YouTube&oldid=849531”

categories Uncategorized | January 2, 2021 | comments Comments (0)

US Supreme Court upholds ban on partial birth abortions

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US Supreme Court upholds ban on partial birth abortions

Wednesday, April 18, 2007

The Supreme Court of the United States on Wednesday April 18 has upheld the federal Partial-Birth Abortion Ban Act of 2003. The 5-4 vote reflected the change in vote count resulting from the retirement of Justice O’Connor and the confirmation of Chief Justice Roberts and Justice Alito.

The Intact dilation and extraction procedure, also known as partial birth abortion, involves removing an intact late-term fetus from the womb via the cervix. While it is a relatively rare operation – 0.17% of all abortions in the US in 2000, it has become a focal point in the abortion debate.

The Partial-Birth Abortion Ban Act bans the procedure in cases where the fetus is terminated during the operation, unless it is performed to to save the life of the mother.

Justice Kennedy wrote in the opinion of the court: “respondents have not demonstrated that the Act would be unconstitutional in a large fraction of relevant cases.” Further, he said, “Respondents have not demonstrated that the Act, as a facial matter, is void for vagueness, or that it imposes an undue burden on a woman’s right to abortion based on its overbreadth or lack of a health exception. For these reasons the judgments of the Courts of Appeals for the Eighth and Ninth Circuits are reversed.”

In a concurring opinion, Justice Thomas stated that he joins “the Court’s opinion because it accurately applies current jurisprudence, including Planned Parenthood of Southeastern Pa. v. Casey, 505 U. S. 833 (1992).”

In dissent Judge Ginsburg wrote: “Today’s decision is alarming. It refuses to take Casey and Stenberg seriously. It tolerates, indeed applauds, federal intervention to ban nationwide a procedure found necessary and proper in certain cases by the American College of Obstetricians and Gynecologists.”

Justice Kennedy’s words also recall the complicated issues of standing related to such cases. An issue in Roe v. Wade was the impossibility of any individual having standing in a court proceeding regarding abortion rights, since court proceedings take more than the 9 months of pregnancy, retiring any individual plaintiff’s standing before an appeals process can take place. The criterion of “a large fraction of relevant cases” may effectively deny standing to any plaintiffs who wish to litigate particular restrictions in some relevant future cases.

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categories Uncategorized | December 29, 2020 | comments Comments (0)

Organic Blackheads Removal And Other Homemade Solutions}

Organic Blackheads Removal and Other Homemade Solutions

by

Zach Doherty

I analyze that when people look at you intently, there are two possible causes. The first explanation for why people stare at you is the probability that you are charming and you caught their attention. Meaning to say you’re good-looking. The second reason why people carefully look at you is because they have laser vision and they scan your whole system, looking for imperfection. People staring at your shortcomings can be very painful. This article will discuss a common skin disorder that people are dying to find solutions to.

Acne can come in several forms. One of them is called blackheads. Blackheads appear as small dots that form in groups on top and side of nose. Many dermatologists say that the blackheads are due to the clogging of hair follicles or pores in the skin. Oil, dirt and bacteria can easily block these pores. If you have oily or combination skin type, you’re more likely to struggle with blackheads, since people with these types of skin tends to generate more oil.Effective Blackheads SolutionsIf you are looking for natural solutions to getting rid of blackheads from your face, there are so many homemade acne remedies that you can choose to try. Most of these acne solutions targeted at problem areas such as T-zone. T-zone consists mainly of the forehead, nose and chin areas of our face. These areas are prone to acne and blackheads development because they generate more oil compared to other areas of the face.Homemade Acne Solutions and BlackheadMore and more people resort to the preparations for acne and blackheads to treat themselves. Why? First of all, they are comfortable. You will find these helpful acne and blackheads solutions to the comfort of your own home. Second, they have few side effects, and finally the cost.Let’s use some of the most popular acne and blackheads at home to discuss solutionsHoneyHoney is very effective in treating acne because of its antibacterial properties. You just have to produce heat honey and apply it in acne prone areas for 10 – 15 minutes. Rinse thoroughly.Baking Soda & WaterMix baking soda and water in a deep bowl. Apply the mixture on the skin for several minutes. Use hot water for rinsing.Lemon and Lime JuiceUse these citrus fruits in the affected areas two or three times a day. They can help reduce acne and can minimize the size of the pores as well.Sure, there are so many effective acne and blackheads treatments you can try at home. Pretty sure, apart from honey, baking powder and citrus, there are other effective acne and blackheads treatment you can try. On the other hand, in severe cases of acne and blackheads, it is best to consult a reliable dermatologist.Forehead acne

and blackheads can be very excruciating. Learn the most effective

blackhead removal

and other ways to get rid of acne today.

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Organic Blackheads Removal and Other Homemade Solutions}

categories Oil | December 24, 2020 | comments Comments (0)